Developing biomarker-driven targeted therapies using the NOBO-VERSE™ database.
Novel biomarker - Clonal Hematopoiesis
Clonal hematopoiesis refers to the phenomenon where mutated immune cells proliferate in the blood. Mutated immune cells lead to the expansion of a specific clone of blood cells and chronic inflammation.
- Clonal hematopoiesis is observed in 10–20% of individuals aged 60 and above. This condition significantly increases the risk of developing cardiovascular diseases, hematologic cancers, and chronic age-related diseases.
- To address this, we have developed a data platform, NOBO-VERSE™, designed to efficiently collect and analyze immunosenescence data from elderly populations including over 12,000 healthy individuals and patient groups.
- We have identified multiple diseases associated with clonal hematopoiesis and are actively developing new drugs to treat these diseases by targeting inflammation.